We frequently pick what to do in-game based on the rewards available rather than on what would be most fun. Stumbling on Happiness suggests that this might not be a horrible idea in terms of remembered enjoyment.
The two things you remember most about an experience are the most extreme event and the last one. Take the biggest emotional peak or trough, take your last thoughts, and those will stick with you long after the details have faded. If the best part of a movie is the ending, you will likely remember it fondly, even if an inventory of the moments finds it lacking.
This suggests the game design wisdom of giving out candy at the end of every quest/dungeon. If the experience ends with your receiving a shiny, you will remember it more fondly. (This also argues against making looting take less time, because you want the player to dwell on that shiny moment at the end.) This is an evolutionarily powerful meme that designers do not even need to pursue intentionally; all things being equal, games that give out candy at the end of each unit will be more popular just because human brains place emotional weight on that.
This also suggests the game design folly of risking disappointment. When faced with a loot slot machine, human brains will tend to value the high of winning more than the expected value suggests, but you are still having quite a few people end the dungeon with disappointment. Maybe they will take the boss kill as “ending on a high note,” or they will be happy for the loot roll winner, but that loot roll at the end will not be a high note for most. This suggests the rise of tokenization as a strong meme, because everyone gets a unit of candy.
It should also suggest that the common model of wiping on bosses for days/weeks before passing them is a horrible design. Multiple tries in a night could still mean ending on a win (high note), but every night that ends in a wipe is a raid full of disappointed people, except for those who take solace in “we’re making good progress.” Perhaps this falls under the loot slot machine principle, whereby the occasional wins are valued more than the frequent losses.