According to these threads on the EVE Online boards, a flaw in an optional EVE:Trinity patch sometimes erases the boot.ini in the Windows directory instead of in the EVE Online directory. Unfortunately, c:\boot.ini is one of the main files used during the boot process of windows, and without a proper boot.ini file, Windows simply won’t start. The file is only used in the boot process, so it will run fine until it’s rebooted, at which point, getting the machine up and running again requires some fun tech support-type work.
Putting aside the obvious question, “How did this get past QA,” why would you ever name a file the same thing as an essential part of the OS? That’s just begging for trouble.